Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control
نویسندگان
چکیده
منابع مشابه
Tricarboxylic acid cycle in Pseudomonas aeruginosa.
During the past few years scattered information has appeared which indicates that at least some bacteria probably possess a tricarboxylic acid cycle. Lockwood and Stodola found that Pseudomonas jluorescens formed considerable quantities of a-ketoglutaric acid when growing on a glucose medium under conditions of intense aeration (1). Ajl and Werkman found evidence for at least parts of the conve...
متن کاملTricarboxylic Acid Cycle in Pseudomonas Aeruginosa”
During the past few years scattered information has appeared which indicates that at least some bacteria probably possess a tricarboxylic acid cycle. Lockwood and Stodola found that Pseudomonas jluorescens formed considerable quantities of a-ketoglutaric acid when growing on a glucose medium under conditions of intense aeration (1). Ajl and Werkman found evidence for at least parts of the conve...
متن کاملEffects of carbon sources on antibiotic resistance in Pseudomonas aeruginosa.
The metabolism of branched-chain amino acids, branched-chain acyl derivatives, d-glucose, l-glutamate, and Mueller-Hinton medium was investigated to determine their effects on the growth, lipid composition, and antibiotic susceptibility of Pseudomonas aeruginosa. The unsaturated fatty acid content of the readily extractable lipids was altered by growth on selected branched-chain amino acids and...
متن کامل[Antibiotic susceptibility of Pseudomonas aeruginosa].
The susceptibility of 128 clinical isolates of Pseudomonas aeruginosa against amikacin, kanamycin, gentamycin, minocycline, colistin, chloramphenicol, claforan , piperacillin and carbenicillin were tested. Piperacillin, carbenicillin, amikacin and claforan are effective against at least 54% of strains tested. The susceptibilities of microorganisms to antibiotics were evaluated in different poin...
متن کاملPolyamines increase antibiotic susceptibility in Pseudomonas aeruginosa.
Pseudomonas aeruginosa is an opportunistic human pathogen. Treatment is complicated by frequent acquired resistance to antipseudomonal therapies. Polyamines (cadaverine, putrescine, spermidine, and spermine) are ubiquitous polycationic compounds essential for all living organisms. In a dose-dependent manner, polyamines increased the susceptibility of P. aeruginosa to 14 beta-lactam antibiotics,...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2017
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2016.12.015